Qnexa, the next weight loss 'miracle'?
I was reading in the New York Times today about a new weight loss pill that has not hit the market yet called Qnexa®. The drug was invented by Dr. Thomas Najarian, who opened a weight loss clinic in California in 2001.
Here's what we know so far about Qnexa®:
It was rejected by the FDA in 2010. FDA declined to approve Qnexa® citing the risks of birth defects (specifically cleft palate) and cardiovascular problems.
- The side effects noted are altered tastes, constipation, dizziness, dry
mouth, headache, depression, anxiety, sleep disorders, attention,
memory, language and other cognitive disorders, metabolic acidosis,
increased heart rate, possible renal stones, and
- It has been shown to
reduce weight by significant amounts by it's participants while taking
the drug, but the participants gain the weight back after ceasing
- If approved by the FDA, it will be the first diet pill in 13 years to be approved by the FDA.
consists of two drugs phentermine (a stimulant-also known as Adipex®)
and Topiramate (an anticonvulsant-also known as Topamax®). These both
seem to work well together to quell appetite. These drugs are effective
alone by themselves to stimulate weight loss, but when put together in
specific amount combos, weight-loss far exceeds any weight loss than one
would find by taking either product alone. Topiramate has not been
tested or approved as a weight loss drug, but those who have used it
have had weight-loss as a side effect of it.
the Phentermine supresses appetite quickly the controlled release of
Topiramate decreases appetite and increases satiety throughout the day.
So when the hunger comes back after the initial release of Phentermine
suppressant, the Topiramate kicks in.
Topiramate has blood pressure lowering effects and has resulted in drops
of systolic blood pressure (the upper number in a blood pressure
reading) at one year. The drug has allowed participants to reduce their
blood pressure medication.
- Qnexa is
prescribed once daily. Upon approval, candidates may include people
with BMI** of 27 to 30. A BMI of 25 or over is considered overweight. A
BMI of 30 or over is considered obese.
of the requirements for the FDA for the drug to be considered as an
obesity fighting drug is it must have at least a third of it's test
patients lose 5% or more body weight, and Qnexa®
has passed this test easily.
- Even though the
drug has not yet been approved, the two drugs Phentermine and
Topiramate taken together in specific amounts discovered by Vivus Inc*,
are essentially the same thing and are currently being prescribed
together by obesity doctors.
My honest opinion (as you could probably guess)? Just exercise and eat a
diet that is as close to nature as possible. This just seems really
silly and lots of hoopla. Your body is designed to move and eat things
that are as close to nature as possible. Don't let someone else deem
what is 'safe' for you. Most parameters set by organizations of
whether things you ingest or are 'safe' for you is whether or not kills
you. You are given an appetite for a reason. Why is it that
advertisers are always trying to suppress it? Makes no sense.....
Inc is the company from California that has been experimenting with
this 'affective combination' for several years and have released
formulations of the drug to produce the trial diet pill.
**A BMI uses height and weight to guestimate body fat levels.
- Teratogenicity is the ability to cause developmental anomalies in a
fetus. The greek root meaning is "monster", which is a reference to the
fact that some developmental abnormalities were viewed as